When Jacques Lacan coined the term "méconnaisance" or "misrecognition," he was referring to the way in which a maturing subject comes to understand his or her encounter with his or her own reflection in the mirror—a psycho-developmental period also known as The Mirror Stage; this encounter, as Lacan theorized, leads to the emergence of an idealized projection of who the subject is. This "Ideal I" that emerges from this encounter with the virtual Other, that is nonetheless the Self, produces both (...) a recognition and a misrecognition of this "I".On the one hand, it produces a recognition of the Self as a coherent body in which this "I" is located. On the other hand, it takes us to a misrecognition of the... (shrink)

Este ensayo aborda uno de los debates más álgidos del feminismo contemporáneo, a saber, la disputa entre quienes abogan por el reconocimiento de las identidades trans mediante la autodeterminación del género y quienes sostienen que esto último representa una amenaza para los marcos jurídicos imperantes. En este texto reconstruyo ambas concepciones empleando las herramientas de la metafísica analítica y los estudios de género. Distingo así entre la identidad materialmente fundamentada y la identidad nomenclatural autoadscriptiva. El objetivo central, más allá de (...) ofrecer esta caracterización, es examinar cuál de estas concepciones es más compatible con una concepción de la justicia que ponga en el centro las libertades de los individuos. (shrink)

Introducción al dosier: Debates Filosóficos sobre el cuerpo sexuado: identidades trans, sujetos políticos e inclusión.

This paper addresses the role of time scales in conceptualizing biological hierarchies. So far, the concept of hierarchies in philosophy of science has been dominated by the idea of composition and parthood, respectively. However, this view does not exhaust the diversity of hierarchical descriptions in the biosciences. Therefore, we highlight a type of hierarchy usually overlooked by philosophers of science. It distinguishes processes based on the different time scales (i.e. rates, frequencies, and rhythms) on which they occur. These time scale (...) hierarchies often are connected with assumptions defended in process ontology. Due to their ability to describe interlevel dynamics of various kinds, we call these hierarchies ‘dynamic hierarchies.’ In order to highlight and discuss their organization, explanatory roles, and epistemic virtues we focus on dynamic hierarchies in developmental biology and evolutionary developmental biology (evo-devo). In these fields, dynamic hierarchies offer crucial complementary information to descriptions of compositional hierarchies. (shrink)

A comienzos de 2017 Rebecca Tuvel publicó un texto intitulado In Defense of Transracialism; este texto defendía que las razones que tenemos para aceptar la transgeneridad/transexualidad deberían, llevarnos a aceptar a la transrracialidad como posibilidad dado que tanto la ontología del género como la de la raza compartían dos elementos fundamentales: la autoidentificación y el etiquetamiento por parte de terceros. En el presente trabajo se cuestiona la validez de esta extrapolación al señalar que ésta conduce a análisis metafísicos y políticos (...) que ignoran tanto la historicidad como la materialidad que caracterizan a las diversas categorías así homologadas. De allí que aquí se cuestione críticamente cierta tendencia que ha igualado diversas ontologías sociales, por un lado, mientras que, por otro, se enfatizan otros abordajes metafísicos que no incurren en estas problemáticas. (shrink)

A biogenetic structural explanation is offered for the cross‐culturally common mystical experience called portalling, the experience of moving from one reality to another via a tunnel, door, aperture, hole, or the like. The experience may be evoked in shamanistic and meditative practice by concentration upon a portalling device (mirror, mandala, labyrinth, skrying bowl, pool of water, etc.). Realization of the portalling experience is shown to be fundamental to the phenomenology underlying multiple reality cosmologies in traditional cultures and is explained in (...) terms of radical re‐entrainment of the neurological systems mediating experience in the brain. Phenomenological experiments with mirror portalling devices from both the Tibetan and the Tsimshian religious traditions are reported. (shrink)

El pensamiento de P. F. Strawson ofrece un difícil equilibrio entre una tendencia naturalista no reduccionista y una trascendental post-kantiana. Este escrito reconsidera un argumento de la estrategia strawsoniana que fue utilizado por Barry Stroud en su famosa crítica a los argumentos trascendentales de los años 60. La reflexión sobre el fin y el alcance de este tipo de argumentos no sólo intenta mostrar la compatibilidad de ambos aspectos en el pensamiento de Strawson, sino iluminar el carácter de necesidad de (...) las proposiciones metafísicas. (shrink)

The “Spiritual Animal Kingdom” is an often-misunderstood section of G.F.W. Hegel’s Phenomenology of Spirit. Many scholars interpret the ‘Spiritual Animal Kingdom’ as being analogous to intellectual life. While the intellectual life analogy is useful, the restrictive account takes it to be the sole content of this section. In this essay, I argue that the restrictive account misidentifies what Hegel means by die Sache selbst (in English, “the matter in hand”). Such a mistake will affect the ability of consciousness to progress (...) to absolute knowing, the ultimate project for Hegel’s Phenomenology. (shrink)

The essential role of creativity has been highlighted in several human knowledge areas. Regarding the neural underpinnings of creativity, there is evidence about the role of left dorsolateral prefrontal cortex (DLPFC) and left inferior frontal gyrus (IFG) on divergent thinking (DT) and convergent thinking (CT). Transcranial stimulation studies suggest that the left DLPFC is associated with both DT and CT, whereas left IFG is more related to DT. However, none of the previous studies have targeted both hubs simultaneously and compared (...) transcranial direct current stimulation (tDCS) and random noise stimulation (tRNS). Additionally, given the relationship between cognitive flexibility and creativity, we included it in order to check if the improvement in creativity may be mediated by cognitive flexibility. In this double-blind, between-subjects study, 66 healthy participants were randomly assigned to one of three groups (N = 22) that received a transcranial direct current stimulation (tDCS), transcranial random noise stimulation (tRNS), or sham for 20 min. The tDCS group received 1.5 mA with the anode over the left DLPFC and cathode over the left IFG. Locations in tRNS group were the same and they received 1.5 mA of high frequency tRNS (100–500 Hz). Divergent thinking was assessed before (baseline) and during stimulation with unusual uses (UU) and picture completion (PC) subtests from Torrance Creative thinking Test, whereas convergent thinking was evaluated with the remote association test (RAT). Stroop test was included to assess cognitive flexibility. ANCOVA results of performance under stimulation (controlling for baseline performance) showed that there were significant differences in PC (F = 3.35, p = 0.042, np2 = 0.10) but not in UU (F = 0.61, p = 0.546) and RAT (F = 2.65, p = 0.079) scores. Post-hoc analyses showed that tRNS group had significantly higher scores compared to sham (p = 0.004) in PC. More specifically, tRNS showed higher performance in fluency (p = 0.012) and originality (p = 0.021) dimensions of PC compared to sham. Regarding cognitive flexibility, we did not find any significant effect of any of the stimulation groups (F = 0.34, p = 0.711). Therefore, no further mediation analyses were performed. Finally, the group that received tDCS reported more adverse effects than sham group (F = 3.46, p = 0.035). Altogether, these results suggest that tRNS may have some advantages over tDCS in DT. (shrink)

Memory has long been a subject of fascination for poets, artists, philosophers and historians. The volume examines how past events are remembered, contested, forgotten, learned from and shared with others. Each author in The Ashgate Research Companion to Memory Studies has been asked to reflect on his or her research companions as a scholar, who studies memory. The original studies presented in the volume are written by leading experts, who emphasize both the continuity of heritage and tradition, as well as (...) the memory of hostilities, traumas and painful events. Comprised of four thematic sections, The Ashgate Research Companion to Memory Studies provides a comprehensive overview of the latest research within the discipline. The principal themes include: ¢ Memory, History and Time ¢ Social, Psychological and Cultural Frameworks of Memory ¢ Acts and Places of Memory ¢ Politics of Memory, Forgetting and Democracy. (shrink)

The Enchantment of Words is a study of Wittgenstein's early masterpiece, the Tractatus Logico-Philosophicus. Recent years have seen a great revival of interest in the Tractatus. McManus's study of the work offers novel readings of all its major themes and sheds light on issues in metaphysics, ethics and the philosophies of mind, language, and logic.

In this article I explore the ways in which legal language, discourses, and narratives construct new dominant identities for women who kill their children. These identities are those of the ‘bad’, ‘mad’, or ‘sad’ woman. Drawing upon and critiquing statutes, case law, and sentencing remarks from England and Wales, I explore how singular narrative identities emerge for the female defendants concerned. Using examples from selected cases, I highlight how the judiciary interpret legislation, use evidence, and draw upon gender stereotypes in (...) carefully constructing macro-narratives which produce gendered identities for filicidal women, thus nullifying the challenge these women pose to appropriate femininity and the motherhood mandate. Each of the narrative identities discussed deny the agency of the female defendants that they are attached to, albeit in subtly different ways, by denying their ability to make any degree of choice in relation to their filicidal actions. Although such identity construction and agency denial may not always be damaging to these filicidal women per se, its pervasiveness within legal discourse reinforces and reproduces damaging gender stereotypes surrounding women and femininity. (shrink)

April 15, 2024: This article published in Early View in error. The article will republish shortly.

This landmark work provides a systematic introduction to systems of modal logic and stands as the first presentation of what have become central ideas in philosophy of language and metaphysics, from the "new theory of reference" and non-linguistic necessity and essentialism to "Kripke semantics.".

Philosophy for Linguists provides students with a clear, concise introduction to the main topics in the philosophy of language. Focusing on what linguists need to know and how philosophy relates to modern linguistics, the book is structured around key branches of linguistics: semantics, pragmatics, and language acquisition. Assuming no prior knowledge of philosophy, Siobhan Chapman traces the history and development of ideas in the philosophy of language and outlines the contributions of specific philosophers. The book is highly accessible and (...) includes: a general introduction and introductions to each chapter; numerous examples and quotations; comprehensive suggestions for further reading and an extensive glossary of linguistic terms. (shrink)

Liberal egalitarian jurisprudence and critical legal studies have often been at odds, despite sharing a core of set of political and analytical commitments. This paper makes the case for their conciliation in the 21st century on the basis that both traditions have much to offer one another. Liberal egalitarians offer the theoretical tools for developing an egalitarian normative approach to law, and critical legal theorists offer a vital realism about power.

Paul Grice (1913-1988) is best known for his psychological account of meaning, and for his theory of conversational implicature. This is the first book to consider Grice's work as a whole. Drawing on the range of his published writing, and also on unpublished manuscripts, lectures and notes, Siobhan Chapman discusses the development of his ideas and relates his work to the major events of his intellectual and professional life.

Although it has acquired an extraordinary social diffusion, entrepreneurial education has a certain lack of definition associated with its conceptualisation and meaning. It seems clear that entrepreneurial education is linked to the economic sphere, but it is not limited to the productive sector. The idea of entrepreneurial education has been progressively enriched, being linked to the development of skills for personal growth and social progress. Further clarification of the meaning and scope of entrepreneurial education is, therefore, needed. Thus, it is (...) relevant to analyse entrepreneurial identity in the context of personal identity via the theoretical–explanatory investigation of a model developed in two phases. A critical analysis leads us to study the different factors that intervene in the configuration of this identity in an attempt to construct a systemic map of entrepreneurial action. Between the private and the public, entrepreneurs seek new ways of facing the challenges of our times, trying to find new ways of regenerating the links between individuals and institutions and with society in general. In this sense, we show how entrepreneurial educational ecosystems acquire relevance insofar as they consider the subject as the principle of action rather than merely the result of various contextual factors. (shrink)

Approximately 15% of couples are affected by infertility worldwide. Subsequently, the use of assisted reproductive technologies is becoming increasingly popular, including the use of donor eggs, sperm and embryos. Despite ongoing ethical debate surrounding gamete donation, this is now a widely accepted practice in Western countries. Assisted reproductive technology is becoming more commonly utilised within the Muslim population; however, gamete donation remains a relatively controversial and taboo topic within this religion. Interestingly, there are significant differences in beliefs between Sunni and (...) Shi’a Muslims. Whilst Sunni Islam absolutely forbids the use of third-party reproductive assistance, Shi’a Islam is somewhat more lenient towards this practice. Reproductive tourism has therefore become prevalent in Shi’a Middle Eastern countries that permit the use of donor gametes in assisted reproductive technologies; however, this continues to evoke a strong bioethical debate, particularly around sperm donation. With the increased influx of reproductive tourism, this is beginning to weaken the regional Sunni Islam ban on the use of donor technologies, questioning the morality of their current beliefs. Consideration of religious beliefs is also crucial for patient-centred care in UK patients treated by the National Health Service for fertility issues. Of note, there is a lack of non-Caucasian donors in the United Kingdom. Reproductive tourism is also becoming increasingly common in the United Kingdom and needs to be considered in terms of future patient management in delivering good obstetric care. (shrink)

This book compares attitudes to empiricism in language study from mid-twentieth century philosophy of language and from present-day linguistics. It focuses on responses to the logical positivism of the Vienna Circle, particularly in the work of British philosopher J. L. Austin and the much less well-known work of Norwegian philosopher Arne Naess.

De acuerdo con la crítica especializada, Aristóteles consolida el saber acumulado sobre los principios de la investigación filosófica y extrae sustancia de aquel saber para impulsar sus propios e innovadores desarrollos teórico-metodológicos, con los cuales labra y apuntala su filosofía crítica y autocrítica. La reconstrucción aristotélica de la historia crítica de la filosofía en sus cimientos y bases formativas no es en modo alguno un recuento mecánico de los desarrollos labrados por los filósofos precedentes y antecesores, sino que el filósofo (...) responde a los desafíos cognitivos que los problemas filosóficos, considerados en sí mismos, suponen e implican para el investigador que busca la verdad tanto acerca del origen del problema filosófico como acerca del origen, desarrollo y evolución de la filosofía. Mirando la tradición, para Aristóteles es claro que la filosofía ha introducido una nueva mirada sobre el mundo, la naturaleza, el ser humano y el horizonte vital de la humanidad. En la medida en que, con la tradición filosófica, contribuye a sepultar la visión mítico-religiosa, su imagen acabada, perfecta del mundo, Aristóteles contribuye también a fortalecer y robustecer la actitud y la visión científico-filosóficas que el pensamiento crítico-reflexivo viene labrando desde que fuera puesto en acto por los primeros y más tempranos filósofos. El presente artículo sostiene que Aristóteles emplea la medicina como recurso argumentativo para explicar que la imagen científica del mundo está condenada a ser incompleta, inacabada e imperfecta precisamente porque está libre del lastre dogmático del mito y porque se define, además, por su carácter crítico-experimental. (shrink)

ABSTRACT This article focuses on Arne Naess's work in the philosophy of language, which he began in the mid-1930s and continued into the 1960s. This aspect of his work is nowadays relatively neglected, but it deserves to be revisited. Firstly, it is intrinsically interesting to the history of analytic philosophy in the twentieth century, because Naess questioned some of the established philosophical methodologies and assumptions of his day. Secondly, it suggests a compelling but unacknowledged intellectual pedigree for some recent developments (...) in linguistics. Naess's philosophy of language developed from his reaction against logical positivism, in particular against what he saw as its unempirical assumptions about language. He went on to establish ?empirical semantics?, in which the study of language was based on real-life linguistic data, drawn primarily from questionnaires issued to philosophically naïve subjects. He also experimented with methods for ?occurrence analysis?, but concluded that the collection and analysis of sufficiently large bodies of naturally-occurring data was impractical. Empirical semantics was not well received by Naess's philosophical contemporaries. It was also seen as being at odds with contemporary trends in linguistics. However, some present-day branches of linguistics have striking resonances with Naess's work from as much as seventy years ago. In sociolinguistics, questionnaires have become an established means of collecting linguistic data. In corpus linguistics, advances in technology have made Naess's unobtainable ideal of ?occurrence analysis? a viable methodology. Some of the principal conclusions reached as a result of this methodology are strikingly similar to Naess's own findings. (shrink)

After examining certain general characteristics of philosophical terminology which are important for the translation of the terms, the author studies the translation of philosophical lexis in a corpus of texts, highlighting the difference in treatment of technical terms and general lexis. A more detailed study of the corpus reveals complexities beyond that binary dichotomy. The author then aims to produce explanations for the translational practice which have been adduced. This necessitates exploring the social context in which the translated terms circulate.

A reference guide to the work of figures who have played an important role in the development of ideas about language.

The COVID-19 pandemic has impacted medical care in many ways; previously, a patient would enter a hospital and had an approximate idea of what would happen upon his admission, the physician informed them about it, but in the last two years this scenario has changed. Therefore, our aim was to identify if bioethical principles are present in the physician–patient relationship and the effect of these in the health care provided, through an observational and descriptive study where patients answered the validated (...) ReMePaB questionnaire that measures the presence of bioethical principles in the physician–patient relationship, on the seventh day of their hospital stay and 24 h after discharge, during the period from 1 August to 5 November 2020. In autonomy, an improvement in the score was observed in the second application compared to the first measurement; in the principle of non-vulnerability, the same scenario was observed for the first and second measurements, respectively. In the principles of beneficence, dignity, and justice, no statistically significant differences were observed. Considering the presence or absence of bioethical aspects in health care in this pandemic creates an area of opportunity to know the feelings of the patient during the care received and to maintain what is done well and improve those aspects that can be improved. (shrink)

Imprecise probabilism—which holds that rational belief/credence is permissibly represented by a set of probability functions—apparently suffers from a problem known as dilation. We explore whether this problem can be avoided or mitigated by one of the following strategies: (a) modifying the rule by which the credal state is updated, (b) restricting the domain of reasonable credal states to those that preclude dilation.

Analyst in training -- Becoming a philosopher -- Science, logic, and language -- Cambridge analysis -- Logical positivism and philosophy of language -- Wider audience -- Politics and critical thinking -- Logic and ideals -- Stebbing, philosophy, and linguistics.

With Wind Wizard, Siobhan Roberts brings us the story of Alan Davenport, the father of modern wind engineering, who investigated how wind navigates the obstacle course of the earth's natural and built environments--and how, when not properly heeded, wind causes buildings and bridges to teeter unduly, sway with abandon, and even collapse. In 1964, Davenport received a confidential telephone call from two engineers requesting tests on a pair of towers that promised to be the tallest in the world. His (...) resulting wind studies on New York's World Trade Center advanced the art and science of wind engineering with one pioneering innovation after another. Establishing the first dedicated "boundary layer" wind tunnel laboratory for civil engineering structures, Davenport enabled the study of the atmospheric region from the earth's surface to three thousand feet, where the air churns with turbulent eddies, the average wind speed increasing with height. The boundary layer wind tunnel mimics these windy marbled striations in order to test models of buildings and bridges that inevitably face the wind when built. Over the years, Davenport's revolutionary lab investigated and improved the wind-worthiness of the world's greatest structures, including the Sears Tower, the John Hancock Tower, Shanghai's World Financial Center, the CN Tower, the iconic Golden Gate Bridge, the Bronx-Whitestone Bridge, the Sunshine Skyway, and the proposed crossing for the Strait of Messina, linking Sicily with mainland Italy. Chronicling Davenport's innovations by analyzing select projects, this popular-science book gives an illuminating behind-the-scenes view into the practice of wind engineering, and insight into Davenport's steadfast belief that there is neither a structure too tall nor too long, as long as it is supported by sound wind science. (shrink)

In the autumn of 1959, Arne Naess and J. L. Austin, both pioneers of empirical study in the philosophy of language, discussed their points of agreement and disagreement at a meeting in Oslo. This article considers the fragmentary record that has survived of that meeting, and investigates what light it can shed on the question of why the two philosophers apparently found so little common ground, given their shared commitment to the importance of data in the study of language. Naess (...) and Austin held different views about two significant aspects of the relationship between scientific method and philosophical investigation. The first aspect concerns the nature of experimental data; Naess used the statistical analysis of data collected from non-philosophical informants while Austin advocated deliberation leading to agreement over usage by a few skilled experts. The second aspect relates to their respective attitudes to the role of theory in philosophical inquiry, attitudes which drew on discussions of scientific method, and its relevance to philosophy, from the early decades of the twentieth century. This article traces the evidence for these views on scientific method in Naess’s and Austin’s respective published work, and in the record of their Oslo meeting. It concludes with a brief overview of opinions about scientific method manifest in the decades since that meeting in various branches of linguistics. These opinions speak to the enduring importance of attitudes to scientific method in relation to our study and understanding of human language. (shrink)

Este artículo reseña: Andrés GARCÍA INDA, La dulce militancia. Crítica de la razón indignada,prólogo de Chaime Marcuello Servós, ediciones Mensajero, Bilbao, 2020, 167 pp.

This paper straightforwardly addresses one of the strongest, from an ethical perspective, objections presented to the duty to die, the one concerned with the lack of a normative theory to support it, offered by Seay in his paper Can there be a “duty to die” without a normative theory? The aim of the paper is to provide strong metaethical grounds to support the duty to die without the need of a moral normative theory. First, the definition and main argument for (...) the duty to die will be presented. Second, Seay’s objection will be described and clearly explained. Third, our metaphysical assumptions and a preliminary metaethical discussion will be offered to situate and understand the context. Finally, we will show how the duty to die can be integrated within the metaethical approach previously presented, defending that there is no need of a normative theory to provide good justification and strong ethical grounds for the duty to die, because they will have already been provided by our metaethical argument. (shrink)

Although natural philosophers of Enlightenment Europe shared common ideals, like reliance on reason and natural philosophy, to promote what they deemed to be progress; there were national differences in attitude and disciplinary focus. This paper takes various eligibility criteria as a starting point from which to define a Nordic Enlightenment science; and situates endeavours in climate science within visions of useful science and international conventions for scientific practice. Two perspectives are explored: the make-up of the Nordic Enlightenment science; and the (...) Nordic natural philosopher’s various platforms for work and knowledge transfer. While historians differ as to what constitutes Enlightenment thought and spirit, I establish the existence of a Nordic Enlightenment science by identifying and examining several of its indicators. The paper concludes with a more specific discussion of climate science in Norway in which I show how climate observations performed during the eighteenth century by a sample of Norway’s clergymen and civil servants bear testimony to an internationally-oriented science, through articles produced for science journals and conventions followed for data presentation and instrumentation. The findings corroborate existing knowledge of a progress-driven, Enlightenment science in Nordic countries; reveal differences between countries, and present Norway’s early-modern climate science in an international light. (shrink)

This chapter considers some of the philosophical writings of Alice Ambrose (1906–2001) and Margaret MacDonald (1903–1956), particularly in relation to their responses to Russell’s work. It argues that both need to be recovered and reconsidered as significant philosophers in their own right, who have important contributions to make to the familiar problems posed by ordinary language in relation to philosophy. Ambrose worked mainly in mathematics and symbolic logic and her earliest publications drew a critical response from Russell himself. Responding in (...) turn to the work of Russell, among others, she went on to bring clarity to the various ways in which ordinary language featured in contemporary philosophical discussion, and identified the centrality of ‘linguistic innovation’ to much philosophical practice. MacDonald found much to agree with in Russell’s work on analysis, but she, too, was troubled by his dismissive attitude to ordinary language. She argued that many philosophical problems can be solved by understanding how language is ordinarily used, and published her case before more celebrated ‘ordinary language philosophers’, most notably J. L. Austin. She also set out ideas and terminology which were later to be associated with Austin’s speech act theory in her contributions to ethics and aesthetics. Both Ambrose and MacDonald contributed to and extended the application of the study of ordinary language in analytic philosophy in ways which deserve to be recovered and to be subjected to further philosophical scrutiny. (shrink)

Godwin's controversial claim for earthly immortality in the first edition of Political Justice has been largely dismissed by scholars as a flaw in his philosophy or as absurd speculation which Godwin cannily omitted from the later editions of the text. In this paper, I will demonstrate, not only that such claims were not nearly as idiosyncratic or eccentric as they have been presented, but that they constitute an intrinsic part of his overall philosophy regarding perfectibility and human progress. Moreover, by (...) examining the revisions made to Political Justice in the second and third editions, it will be possible to prove that the essence of his argument regarding material immortality was not as radically altered as is widely accepted. I will further show how the population controversy of the 18th century forced Godwin to apply his perfectibilist theory to contemporary demographic challenges and how he defended his concept of immortality from both the principle of population and, more particularly, Malthusian philosophy. (shrink)

Recent magnetic resonance imaging and pathological studies have indicated that axonal loss is a major contributor to disease progression in multiple sclerosis. 1 H magnetic resonance spectroscopy, through measurement of N -acetyl aspartate, a neuronal marker, provides a unique tool to investigate this. Patients with primary progressive multiple sclerosis have few lesions on conventional MRI, suggesting that changes in normal appearing white matter, such as axonal loss, may be particularly relevant to disease progression in this group. To test this hypothesis (...) NAWM was studied with MRS, measuring the concentration of N -acetyl derived groups. Single-voxel MRS using a water-suppressed PRESS sequence was carried out in 24 patients with primary progressive multiple sclerosis and in 16 age-matched controls. Ratios of metabolite to creatine concentration were calculated in all subjects, and absolute concentrations were measured in 18 patients and all controls. NA/Cr was significantly lower in NAWM in patients than in controls, as was the absolute concentration of NA. There was no significant difference in the absolute concentration of creatine between the groups. This study supports the hypothesis that axonal loss occurs in NAWM in primary progressive multiple sclerosis and may well be a mechanism for disease progression in this group. (shrink)